Systemic lupus erythematosus is a deadly and incurable disease in which T follicular helper (Tfh) cells play a key role in pathogenesis of autoantibody production and progression of organ damage. Tfh cells also play a key role in a number of other incurable human diseases. Unfortunately, no clinical interventions currently exist for selective depletion of Tfh cells to alleviate these diseases. In this webinar, Dr. Stephen Waggoner at Cincinnati Children's Hospital Medical Center will discuss an engineered chimeric antigen receptor (CAR) facilitating specific targeting of cells with high expression levels of human programmed cell death protein 1 (PD-1), a cardinal feature of Tfh cells. This CAR could potentially advance as a clinical tool for selective depletion of pathogenic follicular T cells or other PD-1 high-target cells in certain disease states.