The presence of subvisible viral aggregates can indicate significant stability issues, reduced product efficacy, and potential risk to patients. Yet most vector analytics programs for gene therapies rely on particle analysis methods that only measure in the sub-micron range - such as DLS and SEC – and can miss subvisible aggregates entirely.
Halo Labs introduces Backgrounded Membrane Imaging (BMI) for reliable, low volume subvisible AAV aggregate analysis. Subvisible particle analysis with BMI is fast, easy, and requires only 25 μL per sample — making characterization of larger, insoluble aggregates finally feasible for vector analytics.