Aspects of High Throughput Molecular Data Analysis
The molecular information acquisition is gaining strong presence in every aspect of life. Much of this stems from the decreasing cost of DNA sequencing and computational power. Coupled with the data, computational methods are generating waves of interesting results. Interestingly, we are far from making sense of the extremely complicated molecular data. The more data we generate, the more we realize the complexity of the cellular information processing. These developments bring so many exciting opportunities and challenges. In this presentation, I will review different aspects of how triage of genomics, transcriptomics, epigenetics is changing the way we understand how molecular health translates to individual health. I will also review some of the future challenges related to high throughput data acquisition and data analysis.
For his postdoctoral studies he moved to Yale University. His postdoctoral studies at Yale focused on genomics and analysis of DNA sequencing data. He has taken a particular interest in analysis of functional genomics data that probe complex regulatory processes in human genome. At Yale, he has been involved as a key member in several consortium projects such as ENCODE, modENCODE, and 1000 Genomes.
His research interests cover a large spectrum of topics in computational biology including functional genomics data analysis, non-coding variation, genotype-phenotype associations, cancer genomics, biological networks, and development of novel machine learning methods for biomedical data analysis. He is also working extensively on implications of large genomic data on personal privacy. In this arena, he is developing computational methods that enhance privacy considerations around analysis and sharing genomic data. Dr. Harmanci’s research reveals ways to understand how an individual’s privacy can be protected when their genome is being shared and analyzed in clinical and other settings. His studies has yielded publications in high impact journals like Nature and Science and his projects have been highlighted in the media and in professional journals.
