Pioneering Research in E3 Ubiquitin Ligase Biology and Applications to Drug Discovery

Approximately 40% of human diseases may be attributable to defects in the cellular proteostasis machinery, including the ubiquitin-proteasome system. Accumulation of misfolded, damaged, or aggregated proteins can lead to prolonged stress, accumulation of reactive oxygen species, and cell death. In this webinar, brought to you by Bio-Techne, Jennifer Johnston will discuss how her research of ubiquitin-proteasome system elements, including Parkin E3 ligase, is used to diagnose and treat diseases caused by defects in proteostasis pathways.

Topics to be covered

• The basics of the ubiquitin-proteasome system
• The biology and druggability of ubiquitin E3 ligases
• Modifications of ubiquitin proteins and their therapeutic and diagnostic applications