Integrative Modeling of Biomolecular Complexes

Ezgi Karaca is a computational structural biologist with a specialization in integrative modeling and biomolecular dynamics. She completed her bachelor (2006) and master’s degrees (2008) in the Chemical Engineering Department of Boğaziçi University. During this time, she focused on p73’s tumor suppression network and mechanistic interpretation of sumoylation cascade under the supervision of Prof. Dr. Türkan Haliloğlu and Prof. Dr. Ruth Nussinov (NIH). For her Ph.D., she joined the group of Prof. Dr. Alexandre Bonvin (Utrecht University). Her thesis work was dedicated to the incorporation of various types of experimental data into the modeling of biomolecular complexes. This research granted her the title of “Ph.D. student of the year” (2012). After successfully obtaining her Ph.D. degree, she moved to the European Molecular Biology Laboratory Heidelberg, to carry out her postdoctoral studies in the labs of Prof. Teresa Carlomagno (NMR) and Dr. Orsolya Barabas (X-ray Crystallography). There, she worked at the intersection of experimental and computational techniques, where she developed tools to translate in-house experimental data into high-resolution structures of protein-nucleic acid machines (2013-2016). Since 2017, she is the principal investigator of the computational structural biology group at the Izmir Biomedicine and Genome Institute.