The Epigenetic Landscape During T Cell Exhaustion

Immune dysfunction during chronic infections and cancer leads to disease progression due to T cell exhaustion. In this process, CD8+ T cells fail to form functional memory. T cell exhaustion results in reduced cytokine production, weakened cell proliferation potential, and an altered transcriptional program and epigenetic landscape. By understanding T cell exhaustion mechanisms, researchers aim to enhance T cell immunity and unravel better therapeutic strategies for clinical applications.

In this webinar brought to you by 10x Genomics and The Scientist’s Creative Services Team, E. John Wherry and Debattama Sen will discuss the transcriptional and epigenetic mechanisms behind T cell exhaustion.

Topics to be covered
• Understanding T cell fate decisions
• The epigenetic memory landscape of CD8+ T cells during and after chronic infection