Advanced In Vitro Technologies to Investigate Therapeutic Impact on the Cancer Immunity Cycle
Immuno-oncology is a fast-growing branch of science, with an unprecedented number of immunotherapeutics being developed in recent years. It’s not without its challenges though, and researchers must often balance scalability with physiological relevance.
In this webinar, Dr. Rajendra Kumari and Dr. Gera Goverse will discuss the basics of immuno-oncology and how cancer immunotherapies are studied along each step of the cancer immunity cycle. They will provide an overview of in vivo, ex vivo and in vitro assays available, including both traditional as well as novel assays. They will also describe the importance and applications of several technology platforms including flow cytometry, histology, single cell analysis, cytokine profiling, T cell cytotoxicity, and high content imaging, and highlight relevant examples from the literature that used them.
Key learning objectives:
- What is the cancer immunity cycle? How are the steps of the cycle regulated, and which steps are potential targets for immunotherapeutics?
- Understand the advantages and limitations of 2D, 3D, in vivo, and ex vivo models
- Applications of high-content imaging and why HCI analysis is so valuable for preclinical immuno-oncology research
different environmental factors on both the local and systemic immune system to
suppress their responses in inflammatory disorders and in the field of immuno-oncology.
Since joining the team at Crown Bioscience, Gera has executed the design of many
successful immuno-oncology projects to help national and international customers
discover the full potential of their compounds.
Gera is motivated by studying the complex mechanisms of the regulation of the immune
system, exploring tumor-cell interactions and refining ways to stimulate the immune
responses towards the killing of the tumor.
