Diabetic foot ulcers can be extremely challenging to treat and are associated with a high morbidity and mortality. A recent large randomised controlled trial (RCT), undertaken in the US, found that a single application of a fetal bovine acellular dermal matrix plus standard of care (SOC) is a faster and more effective treatment for these ulcers than SOC alone. This masterclass will explore this evidence base and debate how to optimise use of this dermal scaffold for this indication.