Biofilms are increasingly associated with many chronic infections across the health field. The main problem with chronic infections is that biofilms are difficult to treat as bacteria in biofilms are tolerant to antimicrobials and the immune system. However, we have recently shown that the chronic infections also contain a lot of single cells too and acute infections also contain biofilms. The single cells er probably not comparable to in vitro planktonic bacteria but we do not know the role of the single bacteria. In addition, increasing evidence suggest that the microenvironment within especially chronic infections is special and possibly governs the disease progression and to some extend the treatment recalcitrance.
In this presentation, Thomas will highlight the challenge that biofilms pose in wounds and in implant-related infections, both in relation to treatment but also to the immune system. Thomas will discuss the idea behind the infectious microenvironment and different hypothesis as to how chronic infections initiate.
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In the second session, Samantha will examine:
- Current issues and challenges in accessing healthcare and its potential impact on skin
- Explore definitions of skin integrity, skin frailty and skin health
- Discuss strategies and principles for prevention of skin damage