Scaling up exothermic additions in the labs

15 Minute Webinar

Adding liquids to a reaction mixture is integral to synthetic chemistry. Scaling up from ml to L will often require changes in how these additions need to be made.

From initiating a reaction, quenching, or adding antisolvent as part of a crystallisation, we need to consider consistent and reproducible dosing.

A chemist may face issues with containment, holding temperature of feed stock, viscosity, mass and how to control highly reactive material.

Other considerations might include:

- Manual handling
- Volumetric vs gravimetric
- Pressure equalisation
- Which pumps to use
- Tubing specifications
- Controlling and recording exotherms
- Controlling pH
- Scalable batch repeatability

In this short webinar Steve and Jenna discuss considerations for making controlled liquid additions, give a demo of AVA Lab Control Software, with a case study illustrating how laboratory control software can solve everyday lab problems, and how Radleys helps address the needs of a typical chemist.

The case study from a customer, demonstrates automated liquid additions to a batch process, with built in safety overrides to control reaction exotherms.

Key learning objectives:

1. Understanding common considerations, methods and tools for liquid additions
2. Utilising automation to improve liquid additions
3. Improved repeatability and reproducibility

Who should attend?

1. Synthetic chemists
2. Scale up chemists
3. University chemists

If you have any issues registering for this webinar, please email webinars@radleys.com