RNA analyses: Overcome the challenges of novel fusion detection

Gene fusions are the latest type of biomarker to receive broad applicability in cancer management. More than 10,000 gene fusions have already been identified in human cancers, and it is estimated that up to 80% of solid tumors could benefit from gene fusion testing. The number of new drug approvals in fusion-positive cancers has been continuously increasing over the last decade. In parallel, more clinical trials are being rolled out to target fusion-positive cancers, hopefully leading to further improvements in treatment options in the near future.

Given the above, clinical researchers need to consider their need for a high-performance fusion detection solution with the ability to detect novel fusions, while taking into account a range of limitations, such as small input amounts, lengthy workflows, and inconvenient interpretation of the results.

In this webinar, Dr Boppudi will share her experience of selecting a solution for fusion detection, including her experience with SOPHiA DDM™ RNAtarget Technology and SOPHiA DDM™ Platform.

During this webinar, our experts and guests will:
- Present considerations for fusion detection in solid tumor oncology
- Discover the features of various technologies for fusion detection with a focus on next-generation sequencing (NGS)
- Get an overview of the SOPHiA DDM™ RNAtarget Technology from SOPHiA GENETICS
- Discuss future directions of fusion detection and RNA analyses, including calling expression changes and single nucleotide variants (SNVs) in RNA

Disclaimer notice:
The term SOPHIA used by the speaker refers to SOPHiA GENETICS and its products.
The opinions expressed during this presentation are these of the speaker and may not represent the opinions of SOPHiA GENETICS.
SOPHiA GENETICS does not provide support in the validation of custom products for clinical use.
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