Despite modern medical advances in various fields of medicine, medical errors are considered the third leading cause of death in the United States. In response to such an alarming fact, both medical schools and graduate medical education accreditation agencies have highlighted the importance of promoting a culture of patient safety and minimizing medical errors while developing quality improvement initiatives. There is, however, a paucity in the methodologies and curricular design activities intended to deliver quality improvement knowledge aimed at minimizing medical errors in medical trainees. Lean Six Sigma, also known as the science of improvement, offers the highest level of combined technical science and soft science available to industries and non-profits today in a single course of study on quality.